Serum transferrin receptor in polycythemia
نویسنده
چکیده
anti-HGV antibodies directed against the E2 structural protein (immunoenzymatic method), a reliable serologic marker of past HGV infection followed by viral clearance.8 Serum specimens were taken at the onset of the disease and stored at –20°C; we found only one patient with HGV positivity by RT-PCR (3%). Twenty-six of 33 patients were positive for anti HGV/E2 antibodies (78.8%) suggesting past infection. This prevalence of HGV RNA was similar to that found in a a population of healthy subjects matched for age and sex, tested as controls (Chi-square test: NS). In contrast, the prevalence of HGV antibodies was significantly higher in the NHL population than in the controls (Chi square test: p< 0.0001: see Table 1). Even if we compare our findings with the prevalence of anti HGV/E2 reported in healthy subjects, drug abusers and blood donors by Tacke et al.,9 the detection of antibodies against HGV/E2 protein is much higher in our HCV postive NHL patients. It must be stressed that the immunoenzymatic method we used for anti HGV/E2 antibodies was tested as highly specific: therefore, cross reaction with antiHCV-E2 antibodies is unlikely. If confirmed, our preliminary data seem to suggest a higher incidence of past HGV infection in our group of HCV postive patients with B cell NHL. Whether or not this has any role (together with HCV) in the etiology or evolution of the neoplastic disease needs to be elucidated.
منابع مشابه
Quantitation and characterization of serum transferrin receptor in patients with anemias and polycythemias.
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